Cellular Selenoprotein mRNA Tethering via Antisense Interactions with Ebola and HIV-1 mRNAs May Impact Host Selenium Biochemistry

Author(s): Ethan Will Taylor, Jan A. Ruzicka, Lakmini Premadasa and Lijun ZhaoPages 1530-1535 (6) Abstract: Regulation of protein expression by non-coding RNAs typically involves effects on mRNA degradation and/or ribosomal translation. The possibility of virus-host mRNA-mRNA antisense tethering interactions (ATI) as a gain-of-function strategy, via the capture of functional RNA motifs, has not been hitherto considered. We present evidence that...

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Biomarkers in the Management of Difficult Asthma

Author(s): Florence Schleich, Demarche Sophie and Louis RenaudPages 1561-1573 (13) Abstract: Difficult asthma is a heterogeneous disease of the airways including various types of bronchial inflammation and various degrees of airway remodeling. Therapeutic response of severe asthmatics can be predicted by the use of biomarkers of Type2-high or Type2-low inflammation. Based on sputum cell analysis, four inflammatory phenotypes have been described....

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Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking

Author(s): Eric P. Trautman and Jason M. CrawfordPages 1705-1716 (12) Abstract: The connection of microbial biosynthetic gene clusters to the small molecule metabolites they encode is central to the discovery and characterization of new metabolic pathways with ecological and pharmacological potential. With increasing microbial genome sequence information being deposited into publicly available databases, it is clear that microbes have the coding...

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The Unexpected Advantages of Using D-Amino Acids for Peptide Self- Assembly into Nanostructured Hydrogels for Medicine

Author(s): Michele Melchionna, Katie E. Styan and Silvia MarchesanPages 2009-2018 (10) Abstract: Self-assembled peptide hydrogels have brought innovation to the medicinal field, not only as responsive biomaterials but also as nanostructured therapeutic agents or as smart drug delivery systems. D-amino acids are typically introduced to increase the peptide enzymatic stability. However, there are several reports of unexpected effects on peptide...

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